The overarching goal of my laboratory is to determine if the nervous system has a broad role in regulation of longevity, and immune responses to infection. Using Caenorhabditis elegans as a model system, we plan to address how sensory perception of cues in the environment or body regulates life-span or susceptibility to an infection. The projects being carried out currently are: Differential regulation of innate immunity to pathogenic microbes (bacteria and fungi) by the nervous system, Do sensory neurons respond directly to bacterial pathogens and whether GPCRs regulate life-span and lipid metabolism in C. elegans.
“Nod2-Nitric Oxide-Responsive Microrna-146A Activates Sonic Hedgehog Signaling To Orchestrate Inflammatory Responses In Murine Model Of Inflammatory Bowel Disease”. Journal of Biological Chemistry 288: 33037–33048. http://dx.doi.org/10.1074/jbc.m113.492496.. 2013.