Sachin Deshmukh

Inspire Faculty / DBT Fellow
Centre for Neuroscience
Research Areas: 
Learning, memory, hippocampus
Research Highlights: 

Dr. Sachin Deshmukh's research interests lie in understanding the neural mechanisms of learning and memory, much of which critically depends on the hippocampus. Understanding the normal process of memory formation in the hippocampal region will facilitate our ability to mitigate the profound memory loss caused by damage to the entorhinal cortex and the hippocampus in Alzheimer’s disease, stroke, traumatic brain injury and epilepsy. Space is the most conspicuous functional correlate of rodent hippocampal neurons. A prominent theory posits that hippocampal “place cells” constitute a spatial framework, and that items and events of experience are organized within this spatial framework to create a “cognitive map”. Cortical inputs to the hippocampus are channelled through the lateral entorhinal cortex (LEC) and the medial entorhinal cortex (MEC). Dr. Deshmukh's primary research interest is to understand how the hippocampal network creates a coherent representation of events within their spatial context. Unravelling the interplay of sensory-derived spatial and nonspatial information brought in by LEC and the internally generated, path-integration-based spatial representation in MEC is a crucial step in this endeavour. Dr Deshmukh's lab records electrical activity of neurons from the entorhinal cortex, the hippocampus and related areas using hyperdrives capable of positioning individual tetrodes in the target regions of the brain to study the interplay between LEC, MEC and the hippocampus.

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