S. S. Indi

Senior Scientific Officer
Microbiology and Cell Biology
Research Areas: 
Electron micrography, neurological disease, Hyper Rayleigh Scattering
Research Highlights: 

My expertise lies in electron micrography and in collaboration with several scientists on campus I have tried to unravel the ultrastructural details of microscopic specimen. My lab works on these specific areas: 1) Studies on Hyper Rayleigh Scattering (HPS) of copper nano particles: Preparing copper nano particles by laser ablation of pure copper or copper oxide using Q switched Nd:YAG laser and making HPS measurements using Nd:YAG laser. 2) Studies on two important neurological diseases: Parkinson's and Alzheimer's diseases are characterized by alpha synuclein filaments and deposition of amyloid plaques respectively. Our studies showed that alpha synuclein exhibits metal specific fibril formation. For Alzheimer's disease, we tested the effect of garlic, known to reduce plaque formation. The aqueous garlic extract not only inhibited the plaque formation but also defibrillate preformed fibrils. This study suggests that consumption of garlic may lead to inhibition of A beta aggregation in human brain. 3) Studies on liposomes as gene delivery system: In this study 15 novel dimeric and three monomeric lipids anchored on an aromatic backbone were designed synthesized and their gene delivery efficacy was studied. 4) Studies on cell division protein FtsZ: Structure-function aspects of bacterial homologue of tubulin, a molecule called FtsZ have been studied. The salient finding of our research includes discovery of first wild type FtsZ (Mycobacterium leprae FtsZ) that does not polymerize under standard condition in vitro. Further it is shown that a single residue at position 172 increases polymerization drastically.

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