Mechanisms of bacterial cell division form the theme of research work in our laboratory. The human bacterial pathogens, Mycobacterium tuberculosis, Mycobacterium xenopi, and Mycobacterium leprae, the saprophyte, Mycobacterium smegmatis, and the enteric bacterium, Escherichia coli are the experimental systems we use to study the phenomenon of bacterial cell division. Specifically, we study the structure and function of the proteins that participate in cell division, regulation of expression of the genes coding for the cell division proteins, and the protein-protein interaction network that regulate cell division. Also, the modes of regulation of cell division under different stress conditions, such as hypoxia, nutrient depletion, and oxidative stress, are also being investigated. Further, an unusual mode of cell division in mycobacteria, the highly deviated asymmetric cell division, which was discovered in our laboratory, is being studied to understand its mechanism and the physiological significance.
“Asymmetric Cell Division In Mycobacterium Tuberculosis And Its Unique Features”. Archives of Microbiology 196: 157–168. http://dx.doi.org/10.1007/s00203-014-0953-7.. 2014.
“Curcumin Reduces The Antimicrobial Activity Of Ciprofloxacin Against Salmonella Typhimurium And Salmonella Typhi”. Journal of Antimicrobial Chemotherapy 68: 139–152. http://dx.doi.org/10.1093/jac/dks375.. 2012.