Dr. Jayanta Chatterjee's research unit in chemical biology is pursuing interdisciplinary research in the areas of peptide-based chemical tools designed to perturb intracellular protein-protein interactions and peptide medicinal chemistry. Some of the questions his group works on are: Can we develop better cancer chemotherapeutics? The laboratory is interested in the development of next-generation cancer chemotherapeutics by targeting protein-protein interaction interfaces inside cancer cells. The idea is to have a targeted therapy that would have less toxic side effects in contrast to the clinically used chemotherapeutics. Can we develop cell-permeable chemical perturbants? The precise understanding of the role of proteins in signal transduction cascades involves their selective perturbation at defined time points. Target specific cell-permeable chemical tools are perfectly suited to reversibly perturb signal transduction events in live cells. The laboratory is actively engaged in developing chemical perturbants and studies their role in signal transduction events. Can we improve pharmacological properties of peptide ligands? Peptides are great candidates as 'leads' towards their development as drugs. However, their in vivo efficacy is remarkably compromised owing to their metabolic instability. One of the research objectives of the laboratory is to actively seek strategies to enhance metabolic stabilities of peptide-based ligands.